An effective method for the treatment of cancer without the associated detrimental side effects has proven elusive. The implementation of nanocarriers as site-specific transport agents has been shown to be a salient potential solution to avoid the systemic effects associated with chemotherapy. Nanocarriers are nanoparticles comprised of a biomaterial or polymer that has been formed into an embeddable matrix and functionalized for site-specific delivery of a nano-payload. In this research, the synthesis of an acrylamide-based polymeric nanoparticle with degradable cross-linkers was performed by a short-chain transfer polymerization in an inverse microemulsion system. The nanoparticles were characterized by dynamic light scattering and transmission electron microscopy. The synthesized nanoparticles were determined to have the intended size and morphology consistent with previous research. The novel synthetic scheme described here to achieve the synthesis was designed for performance in a small-scale research setting.